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Determination of gluten immunogenic peptides (GIP) in urine demonstrates the efficacy of a promising drug therapy for celiac disease
Celiac disease and intestinal damage Celiac disease is an autoimmune disorder with genetic predisposition , which causes villous atrophy due to gluten exposure. Currently the only treatment available is to follow a strict lifelong gluten-free diet (GFD) This follow up achieves to restore the function and normal aspect of the intestinal villi and, thus, the correct nutrient absorption. How does gluten cause damage to the small intestine? Gliadins [...]
Determination of excreted gluten peptides (GIP): milestone in management of Celiac Disease
Is detection of GIP a milestone in the history of Celiac Disease? In the history of Celiac Disease, different stages delimited by various advances in diagnosis and its etiopathogenesis can be considered. Likewise, within these stages, can be highlighted a series of milestones and discoveries for diagnosis, follow-up and treatment of the disease. Evolution and milestones of Celiac Disease Some important milestones in the history of Celiac Disease [...]
How do we measure adherence to gluten-free diet?
Evaluation of adherence to Gluten-free Diet The only treatment for celiac patients is to follow a lifetime gluten-free diet (GFD) in order to recover from the damage of their intestinal villi and avoid other complications associated with Celiac Disease. Usually, the follow-up on GFD is carried out using dietary questionnaires, the analysis of the serological markers or the intestinal biopsy. However, the former are not completely reliable, due [...]
Nasal sample collection reOpenTest
There is evidence that accurate identification of SARS-CoV-2 virus is affected by the source of the samples. Until now, it was known with certainty that the likelihood of obtaining a more accurate diagnosis was increased by collecting the sample by nasopharyngeal swab compared to nasal or oropharyngeal swabs. Fig. 1 Differences between nasal swab, nasopharyngeal swab and oropharyngeal swab. However, sample collection through the nasopharynx does [...]
How to know the immune status after vaccination?
Vaccination against COVID-19 is a crucial part in the fight against the pandemic. Currently, there are different vaccines in this fight, but they all have a common mechanism of action. The vaccine activates the production of specific immunoglobulins against the SARS-CoV-2 virus. Vaccines create antibodies against the Spike protein. But how the effectiveness of a vaccine is determined? Through the antibodies produced by it. Vaccines stimulate responses that [...]
How effective is the COVID-19 vaccine? Rapid serological tests verify in minutes that vaccines have generated antibodies against the virus.
The vaccine is the most promising measure that is carried out for individual protection and collective protection against COVID-19. Protecting yourself from COVID-19 is crucial because, in some cases, the disease can become seriously complicated and even lead to death. Vaccines against COVID-19 help our body develop immunity against the SARS-CoV-2 virus, without become infected with the disease. The protection provided by the vaccine is based on the [...]